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Article

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

6 Jul 2011

Abstract excerpt

Transgenic (Tg) mouse models of Alzheimer's disease (AD) are used to investigate mechanisms underlying disease pathology and identify therapeutic strategies. Most Tg AD models, which at least partly recapitulate the AD phenotype, are based on insertion of one or more human mutations (identified in Familial AD) into the mouse genome, with the notable exception of the anti-NGF mouse, which is based on the...

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PMID: 21732714
DOI: 10.1515/rns.2011.035

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