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Article

APPswe mutation increases the frequency of spontaneous Ca2+-oscillations in rat hippocampal neurons.

Neuroscience letters - 9 May 2008

Kloskowska Ewa, Malkiewicz Katarzyna, Winblad Bengt, Benedikz Eirikur, Bruton Joseph D

Abstract excerpt

Altered calcium homeostasis is implicated in the pathogenesis of Alzheimer's disease (AD). Much effort has been put into understanding the association between protein mutations causative of this devastating neurodegenerative disease and perturbed calcium signaling. Whereas the presenilin mutations have received most attention in the context of neuronal calcium signaling, we focused on the effects of APP with the...

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Identifiers

PMID: 18403114
DOI: 10.1016/j.neulet.2008.03.034

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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