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Article

Age-dependent concomitant changes in synaptic dysfunction and GABAergic pathway in the APP/PS1 mouse model.

Acta neurobiologiae experimentalis - 1 Jan 2016

Oyelami Tutu, Bondt An De, den Wyngaert Ilse Van, Hoorde Kirsten Van, Hoskens Luc, Shaban Hamdy, Kemp John A, Drinkenburg Wilhelmus H

Abstract excerpt

Synaptic dysfunction is a well-documented manifestation in animal models of Alzheimer's disease pathology. In this context, numerous studies have documented reduction in the functionality of synapses in various models. In addition, recent research has shed more light on increased excitability and its link to seizures and seizure-like activities in AD patients as well as in mouse models. These reports of...

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Identifiers

PMID: 28094819
DOI: 10.21307/ane-2017-027

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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