Article
A sorting signal suppresses IFITM1 restriction of viral entry.
The Journal of biological chemistry - 13 Feb 2015
Li Kun, Jia Rui, Li Minghua, Zheng Yi-Min, Miao Chunhui, Yao Yunfang, Ji Hong-Long, Geng Yunqi, Qiao Wentao, Albritton Lorraine M, Liang Chen, Liu Shan-Lu
Abstract excerpt
The interferon-induced transmembrane proteins (IFITMs) broadly inhibit virus infections, particularly at the viral entry level. However, despite this shared ability to inhibit fusion, IFITMs differ in the potency and breadth of viruses restricted, an anomaly that is not fully understood. Here, we show that differences in the range of viruses restricted by IFITM1 are regulated by a C-terminal non-canonical dibasic...
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