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Article

IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry

27 Oct 2011

Abstract excerpt

To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The interferon inducible transmembrane protein family members, IFITM1, 2 and 3, are IEGs required for inhibition of influenza A virus, dengue virus, and West Nile virus replication in vitro. Here we report that IFN...

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PMID: 22046135
DOI: 10.1371/journal.ppat.1002337

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