Colorectal cancer heterogeneity co-evolves with tumor architecture to determine disease outcome

Abstract excerpt

<h4>Summary</h4> Intratumoral heterogeneity, originating from genetic, epigenetic, and phenotypic cellular diversity, is pervasive in cancer. As these heterogeneous states employ diverse mechanisms to promote tumor progression, metastasis, and therapy resistance, emergence of cancer heterogeneity is one of the most significant barriers to curative treatment. Here we leverage deep learning approaches to develop a...

Topics

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• Cancer Cells and Metastasis
• Cancer Genomics and Diagnostics
• Carcinogenesis
• Colorectal Cancer Treatments and Studies
• Mutation
• Pancreatic and Hepatic Oncology Research
• Phenotype
• Stem Cells

Identifiers and source

Literature Corpus work

7b3180a0-90ed-5076-af10-045c9432ef15

DOI

10.1101/2025.08.11.669722