Article

The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells

2021-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Transcription is essential for cells to respond to signaling cues and involves factors with multiple distinct activities. One such factor, TRRAP, functions as part of two large complexes, SAGA and TIP60, which have crucial roles during transcription activation. Structurally, TRRAP belongs to the PIKK family but is the only member classified as a pseudokinase. Recent studies established that a de...

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Literature Corpus work: 7b03ddd4-63ad-5a3f-80b4-681a9d17fadf
DOI: 10.1101/2021.04.13.439699

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