Article

Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression

2023-06-26

Abstract excerpt

<h4>Background</h4> The immunosuppressive tumor microenvironment (TME) of colorectal cancer (CRC) is a major hurdle for immune checkpoint inhibitor-based therapies. Hence characterization of the signaling pathways driving T cell exhaustion within TME is a critical need for the discovery of novel therapeutic targets and the development of effective therapies. We previously showed that i) the adaptor protein Rai is...

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Literature Corpus work: e5d0fccb-9b11-5da2-a2e1-054f4aa3a792
DOI: 10.1101/2023.06.23.546212

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Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expressionDOI 10.1101/2023.06.23.546212Read

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