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Article

TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.

International journal of molecular sciences - 28 Jun 2021

Swain Umakanta, Friedlander Gilgi, Sehrawat Urmila, Sarusi-Portuguez Avital, Rotkopf Ron, Ebert Charlotte, Paz-Elizur Tamar, Dikstein Rivka, Carell Thomas, Geacintov Nicholas E, Livneh Zvi

Abstract excerpt

TENT4A (PAPD7) is a non-canonical poly(A) polymerase, of which little is known. Here, we show that TENT4A regulates multiple biological pathways and focuses on its multilayer regulation of translesion DNA synthesis (TLS), in which error-prone DNA polymerases bypass unrepaired DNA lesions. We show that TENT4A regulates mRNA stability and/or translation of DNA polymerase η and RAD18 E3 ligase, which guides the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34203408
DOI: 10.3390/ijms22136957
PMCID: PMC8267958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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