Article

Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant expression of the embryonal transcription factor TBXT (also known as brachyury) drives chordoma, a rare spinal neoplasm with no effective drug therapies. The gene network regulated by TBXT is poorly understood, and strategies to disrupt its abnormal activity for therapeutic purposes are lacking. Here, we developed TBXT-targeted designed ankyrin repeat proteins (T-DARPins) that selective...

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Literature Corpus work: 2b64233f-d42b-5764-809c-ae105203b6f0
DOI: 10.1101/2024.09.20.614025

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