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Article

New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas

1 Sept 2006

Abstract excerpt

Human epithelial tumors need to accumulate multiple genetic alterations to form invasive carcinomas. These genetic alterations are related with growth factor receptors, cell signalling, the cell cycle and cell invasiveness. Importantly, cells need to avoid senescence and become immortalized for this process. Recently, five genes: RPS6KA6, HDAC4, KIAA0828, TCP1 and Tip60, which modulate p53-dependent function and...

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PMID: 16865262
DOI: 10.3892/or.16.3.603

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