Article

The R2TP chaperone assembles cellular machineries in intestinal CBC stem cells and progenitors

2019-12-19

Abstract excerpt

<h4>Summary</h4> The R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into multi-subunit complexes, yet its role in tissue homeostasis is unknown. Here, we generated conditional, inducible knock-out mice for Rpap3 to inactivate this core component of R2TP in the intestinal epithelium. In adult mice, Rpap3 invalidation caused destruction of the small intestinal epithelium, and death w...

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Literature Corpus work: e8b254e2-d459-5510-b2a8-6fae9b5a0d4e
DOI: 10.1101/2019.12.19.882712

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