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E2F1 promotes, JNK and DIAP1 inhibit, and chromosomal position has little effect on radiation-induced Loss of Heterozygosity in <i>Drosophila</i>

2023-05-12

Abstract excerpt

Loss of Heterozygosity (LOH) can occur when a heterozygous mutant cell loses the remaining wild type allele to become a homozygous mutant. LOH can have physiological consequences if, for example, the affected gene encodes a tumor suppressor. We used two fluorescent reporters to study mechanisms of LOH induction by X-rays, a type of ionizing radiation (IR), in Drosophila larval wing discs. IR is used to treat more...

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Literature Corpus work
7b01a103-12d3-5803-8ff2-6636b574f5dd
DOI
10.1101/2023.05.09.540084
Open publication

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E2F1 promotes, JNK and DIAP1 inhibit, and chromosomal position has little effect on radiation-induced Loss of Heterozygosity in <i>Drosophila</i>DOI 10.1101/2023.05.09.540084
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