Article
A new resource for characterizing X-linked genes in Drosophila melanogaster: systematic coverage and subdivision of the X chromosome with nested, Y-linked duplications.
Genetics - 1 Dec 2010
Cook R Kimberley, Deal Megan E, Deal Jennifer A, Garton Russell D, Brown C Adam, Ward Megan E, Andrade Rachel S, Spana Eric P, Kaufman Thomas C, Cook Kevin R
Abstract excerpt
Interchromosomal duplications are especially important for the study of X-linked genes. Males inheriting a mutation in a vital X-linked gene cannot survive unless there is a wild-type copy of the gene duplicated elsewhere in the genome. Rescuing the lethality of an X-linked mutation with a duplication allows the mutation to be used experimentally in complementation tests and other genetic crosses and it maps the...
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