Article

Single cell transcriptomics reveals tumor heterogeneity in myeloid leukemia associated with Down syndrome

2023-11-16

Abstract excerpt

<h4>Background: </h4> The susceptibility of children with Down syndrome to acute myeloid leukemia especially acute megakaryocytic leukemia (AMKL) is much higher than that of general population. The origination of ML-DS (Myeloid leukemia associated with Down syndrome) cells, the occurrence, development and tumor heterogeneity of ML-DS are still [ambiguous](javascript:;). For children with DS, the incidence of non-A...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7adc262b-4cd6-589f-ac39-4815353e1ef9
DOI: 10.22541/au.170012562.22650364/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell transcriptomics reveals tumor heterogeneity in myeloid leukemia associated with Down syndromeDOI 10.22541/au.170012562.22650364/v1Read

Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.Semantic proximity Read

Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.Semantic proximity Read

Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.Semantic proximity Read

Advances in molecular characterization of myeloid proliferations associated with Down syndromeSemantic proximity Read

Clinical impact of genomic characterization of 15 patients with acute megakaryoblastic leukemia-related malignancies.Semantic proximity Read

Myeloid Leukemia in Down SyndromeSemantic proximity Read

Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms.Semantic proximity Read

Down syndrome and leukemia: An insight into the disease biology and current treatment options.Semantic proximity Read

Clinical and biological aspects of myeloid leukemia in Down syndrome.Semantic proximity Read

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of <i>KMT2A</i> -rearranged leukemiaSemantic proximity Read

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome.Semantic proximity Read

Down syndrome and leukemia: insights into leukemogenesis and translational targets.Semantic proximity Read