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Article

Clinical impact of genomic characterization of 15 patients with acute megakaryoblastic leukemia-related malignancies.

Cold Spring Harbor molecular case studies - 1 Apr 2021

Lalonde Emilie, Rentas Stefan, Wertheim Gerald, Cao Kajia, Surrey Lea F, Lin Fumin, Zhao Xiaonan, Obstfeld Amrom, Aplenc Richard, Luo Minjie, Li Marilyn M

Abstract excerpt

Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia but is approximately 500 times more likely to develop in children with Down syndrome (DS) through transformation of transient abnormal myelopoiesis (TAM). This study investigates the clinical significance of genomic heterogeneity of AMKL in children with and without DS and in children with TAM. Genomic evaluation of nine patients...

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Source

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Identifiers

PMID: 33832921
DOI: 10.1101/mcs.a005975
PMCID: PMC8040732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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