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Article

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome.

Blood - 19 Mar 2009

Malinge Sébastien, Izraeli Shai, Crispino John D

Abstract excerpt

Children with Down syndrome (DS) show a spectrum of clinical anomalies, including cognitive impairment, cardiac malformations, and craniofacial dysmorphy. Moreover, hematologists have also noted that these children commonly show macrocytosis, abnormal platelet counts, and an increased incidence of transient myeloproliferative disease (TMD), acute megakaryocytic leukemia (AMKL), and acute lymphoid leukemia (ALL)....

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Share to Chromosomes, Human, Pair 21
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Janus Kinases

Share to Leukemia, Megakaryoblastic, Acute

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Source

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Identifiers

PMID: 19139078
DOI: 10.1182/blood-2008-11-163501
PMCID: PMC2661853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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