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Article

Down syndrome and leukemia: An insight into the disease biology and current treatment options.

Blood reviews - 1 Mar 2024

Barwe Sonali P, Kolb E Anders, Gopalakrishnapillai Anilkumar

Abstract excerpt

Children with Down syndrome (DS) have a 10- to 20-fold greater predisposition to develop acute leukemia compared to the general population, with a skew towards myeloid leukemia (ML-DS). While ML-DS is known to be a subtype with good outcome, patients who relapse face a dismal prognosis. Acute lymphocytic leukemia in DS (DS-ALL) is considered to have poor prognosis. The relapse rate is high in DS-ALL compared to...

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Identifiers

PMID: 38016838
DOI: 10.1016/j.blre.2023.101154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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