Article

Molecular and Histological Responses to AOM in Apex1 Haploinsufficient Mice Reveal a Protective Role of Ape1 in Liver Tissue

2024-10-07

Abstract excerpt

<title>Abstract</title> <p>Strong evidence indicates that in liver diseases such as cirrhosis and hepatocellular carcinoma, there is a reduction of mitochondrial components, particularly mitochondrial DNA (mtDNA), thus suggesting that loss of mtDNA integrity plays an essential role in the development of liver pathologies. However, little is known about mtDNA repair's contribution to maintaining mtDNA and the prev...

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Literature Corpus work: 7aac9445-63d5-5597-9c77-52da30ab5b7d
DOI: 10.21203/rs.3.rs-4965990/v1

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