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Article

A Mouse Model of Accelerated Liver Aging Caused by a Defect in DNA Repair

27 Sept 2011

Abstract excerpt

UNLABELLED: The liver changes with age, leading to an impaired ability to respond to hepatic insults and increased incidence of liver disease in the elderly. Therefore, there is critical need for rapid model systems to study aging-related liver changes. One potential opportunity is murine models of human progerias or diseases of accelerated aging. Ercc1(-/Δ) mice model a rare human progeroid syndrome caused by...

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PMID: 21953681
DOI: 10.1002/hep.24713

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