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Article

NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations.

Nature communications - 16 Jan 2024

Yang Liang, Ruan Zifeng, Lin Xiaobing, Wang Hao, Xin Yanmin, Tang Haite, Hu Zhijuan, Zhou Yunhao, Wu Yi, Wang Junwei, Qin Dajiang, Lu Gang, Loomes Kerry M, Chan Wai-Yee, Liu Xingguo

Abstract excerpt

Aging in mammals is accompanied by an imbalance of intestinal homeostasis and accumulation of mitochondrial DNA (mtDNA) mutations. However, little is known about how accumulated mtDNA mutations modulate intestinal homeostasis. We observe the accumulation of mtDNA mutations in the small intestine of aged male mice, suggesting an association with physiological intestinal aging. Using polymerase gamma (POLG) mutator...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38228611
DOI: 10.1038/s41467-024-44808-z
PMCID: PMC10791663

Genes

ATF5
POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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