Article
Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress.
Cancer research - 15 Jul 2001
Meira L B, Devaraj S, Kisby G E, Burns D K, Daniel R L, Hammer R E, Grundy S, Jialal I, Friedberg E C
Abstract excerpt
Apurinic/apyrimidinic endonuclease is a key enzyme in the process of base excision repair, required for the repair of spontaneous base damage that arises as a result of oxidative damage to DNA. In mice, this endonuclease is coded by the Apex gene, disruption of which is incompatible with embryonic life. Here we confirm the embryonic lethality of Apex-null mice and report the phenotypic characterization of mice...
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