Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease.

doi:10.1038/s41467-022-28201-2

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Article

Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease.

Nature communications - 28 Jan 2022

Barbier-Torres Lucía, Murray Ben, Yang Jin Won, Wang Jiaohong, Matsuda Michitaka, Robinson Aaron, Binek Aleksandra, Fan Wei, Fernández-Ramos David, Lopitz-Otsoa Fernando, Luque-Urbano Maria, Millet Oscar, Mavila Nirmala, Peng Hui, Ramani Komal, Gottlieb Roberta, Sun Zhaoli, Liangpunsakul Suthat, Seki Ekihiro, Van Eyk Jennifer E, Mato Jose M, Lu Shelly C

Abstract excerpt

MATα1 catalyzes the synthesis of S-adenosylmethionine, the principal biological methyl donor. Lower MATα1 activity and mitochondrial dysfunction occur in alcohol-associated liver disease. Besides cytosol and nucleus, MATα1 also targets the mitochondria of hepatocytes to regulate their function. Here, we show that mitochondrial MATα1 is selectively depleted in alcohol-associated liver disease through a mechanism...

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Identifiers

PMID: 35091576
DOI: 10.1038/s41467-022-28201-2
PMCID: PMC8799735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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