Article
Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.
Molecular and cellular biology - 1 Sept 2008
Martinsson-Ahlzén Hanna-Stina, Liberal Vasco, Grünenfelder Björn, Chaves Susana R, Spruck Charles H, Reed Steven I
Abstract excerpt
Cks proteins associate with cyclin-dependent kinases and have therefore been assumed to play a direct role in cell cycle regulation. Mammals have two paralogs, Cks1 and Cks2, and individually deleting the gene encoding either in the mouse has previously been shown not to impact viability. In this study we show that simultaneously disrupting CKS1 and CKS2 leads to embryonic lethality, with embryos dying at or...
Topics
- Animals
- CDC2 Protein Kinase
- CDC2-CDC28 Kinases
- CDC28 Protein Kinase, S cerevisiae
- Carrier Proteins
- Cell Cycle
- Cell Cycle Proteins
- Cell Proliferation
- Cells, Cultured
- Cyclin A