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Article

Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethality.

PloS one - 1 Jan 2009

Kim Yong, McBride Jim, Kimlin Lauren, Pae Eung-Kwon, Deshpande Amit, Wong David T

Abstract excerpt

Targeted disruption of murine Cdk2ap1, an inhibitor of CDK2 function and hence G1/S transition, results in the embryonic lethality with a high penetration rate. Detailed timed pregnancy analysis of embryos showed that the lethality occurred between embryonic day 3.5 pc and 5.5 pc, a period of implantation and early development of implanted embryos. Two homozygous knockout mice that survived to term showed...

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Source

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Identifiers

PMID: 19229340
DOI: 10.1371/journal.pone.0004518
PMCID: PMC2641017

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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