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Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability

24 Nov 2021

Abstract excerpt

DNA replication must be precisely controlled in order to maintain genome stability. Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) in association with respective cyclin regulatory subunits. In normal cell cycles, E-type cyclins (Cyclin E1 and Cyclin E2, CCNE1 and CCNE2 genes) associate with CDK2 to promote G1/S transition. Cyclin E/CDK2 complex mostly controls...

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PMID: 34901021
DOI: 10.3389/fcell.2021.774845

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