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Article

Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development.

Molecular cancer research : MCR - 1 Nov 2012

Verduzco Daniel, Dovey Jennifer Shepard, Shukla Abhay A, Kodym Elisabeth, Skaug Brian A, Amatruda James F

Abstract excerpt

The early development of vertebrate embryos is characterized by rapid cell proliferation necessary to support the embryo's growth. During this period, the embryo must maintain a balance between ongoing cell proliferation and mechanisms that arrest or delay the cell cycle to repair oxidative damage and other genotoxic stresses. The ataxia-telangiectasia mutated (ATM) kinase is a critical regulator of the response...

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Identifiers

PMID: 22986406
DOI: 10.1158/1541-7786.MCR-12-0072
PMCID: PMC3511848

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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