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Morpho-histological and Transcriptome Analysis Reveal the Unreduced Sperm Formation Mechanism in cdk1-Depletion Zebrafish.

Marine biotechnology (New York, N.Y.) - 1 Dec 2024

Zhang Yunbang, Li Rongyun, Li Hui, Huang Yuwei, Mei Yihui, Zheng Yuxuan, Guo Yankun, Zhou Zihao, Yong Zhonglin, Zhao Ying, Dong Wenjing, Gao Jian, Cao Xiaojuan

Abstract excerpt

Cyclin-dependent kinases (Cdks) are major molecules related to cell cycle regulation. Polyploidy can be caused by the production of unreduced gametes, which is often related to the abnormal cell cycle of germ cells. Here, we successfully constructed a cdk1 mutation line (cdk1+/-) in zebrafish, a commonly used model organism. It showed that cdk1 depletion resulted in the generation of both polyploid and aneuploid...

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PMID: 39243300
DOI: 10.1007/s10126-024-10366-0

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