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A Genetic Variant rs10251977 in Long Non-coding RNA EGFR-AS1 Creates a New Binding Site for miR-891b and Modulates the Expression of EGFR A/D Isoforms

2020-12-31

Abstract excerpt

Tyrosine kinase inhibitor (TKI) is one of the effective chemo-preventive approaches against tumors that deregulate EGFR pathway. About 80% of HNSCC patients overexpress EGFR, making TKI an effective treatment against this cancer. Recently a synonymous variant rs10251977 in exon 20 of EGFR reported to act as a prognostic marker in HNSCC. Analysis of this germline variant in blood samples of oral cancer patients sho...

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Literature Corpus work: 7a94270a-a330-5e3c-b422-bfa7f0c882b4
DOI: 10.21203/rs.3.rs-136285/v1

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