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Article

Genetic variant rs10251977 (G>A) in EGFR-AS1 modulates the expression of EGFR isoforms A and D.

Scientific reports - 22 Apr 2021

Dhamodharan Shankar, Rose Mathew Maria, Chakkarappan Sundaram Reddy, Umadharshini Karuppiah Vijayamuthuramalingam, Arulmurugan Ramalingam, Subbiah Shanmugam, Inoue Ituro, Munirajan Arasambattu Kannan

Abstract excerpt

Tyrosine kinase inhibitor is an effective chemo-therapeutic drug against tumors with deregulated EGFR pathway. Recently, a genetic variant rs10251977 (G>A) in exon 20 of EGFR reported to act as a prognostic marker for HNSCC. Genotyping of this polymorphism in oral cancer patients showed a similar frequency in cases and controls. EGFR-AS1 expressed significantly high level in tumors and EGFR-A isoform expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33888812
DOI: 10.1038/s41598-021-88161-3
PMCID: PMC8062556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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