Article
Annexin A1 regulates EGFR activity and alters EGFR-containing tumour-derived exosomes in head and neck cancers.
European journal of cancer (Oxford, England : 1990) - 1 Oct 2018
Raulf N, Lucarelli P, Thavaraj S, Brown S, Vicencio J M, Sauter T, Tavassoli M
Abstract excerpt
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer with approximately half a million cases diagnosed each year worldwide. HNSCC has a poor survival rate which has not improved for over 30 years. The molecular pathogenesis of HNSCCs remains largely unresolved; there is high prevalence of p53 mutations and EGFR overexpression; however, the contribution of these molecular changes...
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