Mutations in untranslated non-coding regions of EGFR, AKT1 & HRAS modulate their expression regulatory networks to facilitate progression of colorectal cancer.

Abstract excerpt

Mutations in the untranslated region (UTR) of a gene dysregulate its expression by disrupting the regulatory elements. Defective EGFR, AKT1, and HRAS are known to promote colorectal cancer (CRC) by activating oncogenic signaling pathways. The current study aimed to screen the Pakistani CRC patients for UTR mutations of EGFR, AKT1, and HRAS genes and investigate the functional impact of detected mutations on...

Topics

• Humans
• Colorectal Neoplasms
• Proto-Oncogene Proteins c-akt
• ErbB Receptors
• Proto-Oncogene Proteins p21(ras)
• Mutation