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Article

ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.

Oncotarget - 20 Apr 2015

Bill Anke, Gutierrez Abraham, Kulkarni Sucheta, Kemp Carolyn, Bonenfant Debora, Voshol Hans, Duvvuri Umamaheswar, Gaither L Alex

Abstract excerpt

The epidermal growth factor receptor (EGFR) contributes to the pathogenesis of head&neck squamous cell carcinoma (HNSCC). However, only a subset of HNSCC patients benefit from anti-EGFR targeted therapy. By performing an unbiased proteomics screen, we found that the calcium-activated chloride channel ANO1 interacts with EGFR and facilitates EGFR-signaling in HNSCC. Using structural mutants of EGFR and ANO1 we...

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Share to Carcinoma, Squamous Cell
Share to Chloride Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Head and Neck Neoplasms

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Source

Open in PubMed Open full text

Identifiers

PMID: 25823819
DOI: 10.18632/oncotarget.3277
PMCID: PMC4496210

Genes

EGFR
ANO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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