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Article

Involvement of CYP2D6 and CYP2B6 on tramadol pharmacokinetics.

Pharmacogenomics - 1 Jul 2020

Saiz-Rodríguez Miriam, Ochoa Dolores, Román Manuel, Zubiaur Pablo, Koller Dora, Mejía Gina, Abad-Santos Francisco

Abstract excerpt

This study included 24 healthy volunteers who received a single 37.5 mg oral dose of tramadol. We analyzed 18 polymorphisms within CYP2D6, CYP2B6, CYP3A, COMT, ABCB1, SLC22A1 and OPRM1 genes by quantitative PCR, to study whether these polymorphisms affect its pharmacokinetics, pharmacodynamics and safety. CYP2D6 intermediate metabolizers (n = 6) showed higher tramadol plasma concentrations and lower clearance...

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Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cytochrome P-450 CYP2B6

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Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 32538291
DOI: 10.2217/pgs-2020-0026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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