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Article

Mrc1/Claspin: a new role for regulation of origin firing.

Current genetics - 1 Oct 2017

Masai Hisao, Yang Chi-Chun, Matsumoto Seiji

Abstract excerpt

Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. They are likely to be a part of the replisome and facilitate the S-phase progression by promoting replication fork progression. Recent reports on Mrc1/Claspin indicate their new role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28357499
DOI: 10.1007/s00294-017-0690-y

Genes

ATR

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Related research

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Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint.Semantic proximity Read ↗

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