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Article

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.

Current biology : CB - 10 Oct 2006

Mamely Ivan, van Vugt Marcel Atm, Smits Veronique A J, Semple Jennifer I, Lemmens Bennie, Perrakis Anastassis, Medema René H, Freire Raimundo

Abstract excerpt

DNA-damage checkpoints maintain genomic integrity by mediating a cell-cycle delay in response to genotoxic stress or stalled replication forks. In response to damage, the checkpoint kinase ATR phosphorylates and activates its effector kinase Chk1 in a process that critically depends on Claspin ....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16934469
DOI: 10.1016/j.cub.2006.08.026

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16934469-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.PMID 16934469Read ↗

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress.Semantic proximity Read ↗

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.Semantic proximity Read ↗

Roles of Claspin in regulation of DNA replication, replication stress responses and oncogenesis in human cellsSemantic proximity Read ↗

DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response.Semantic proximity Read ↗

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.Semantic proximity Read ↗

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cellsSemantic proximity Read ↗

Drf1-dependent kinase interacts with Claspin through a conserved protein motif.Semantic proximity Read ↗

Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.Semantic proximity Read ↗

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replicationSemantic proximity Read ↗

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