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DNA replication stress: oncogenes in the spotlight

13 Dec 2019

Abstract excerpt

Precise replication of genetic material is essential to maintain genome stability. DNA replication is a tightly regulated process that ensues faithful copies of DNA molecules to daughter cells during each cell cycle. Perturbation of DNA replication may compromise the transmission of genetic information, leading to DNA damage, mutations, and chromosomal rearrangements. DNA replication stress, also referred to as...

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PMID: 31930281
DOI: 10.1590/1678-4685gmb-2019-0138

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