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Article

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.

Molecular cell - 4 Aug 2006

Peschiaroli Angelo, Dorrello N Valerio, Guardavaccaro Daniele, Venere Monica, Halazonetis Thanos, Sherman Nicholas E, Pagano Michele

Abstract excerpt

During replicative stress, Claspin mediates the phosphorylation and consequent activation of Chk1 by ATR. We found that during recovery from the DNA replication checkpoint response, Claspin is degraded in a betaTrCP-dependent manner. In vivo, Claspin is phosphorylated in a canonical DSGxxS degron sequence, which is typical of betaTrCP substrates. Phosphorylation of Claspin is mediated by Plk1 and is essential for...

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Identifiers

PMID: 16885022
DOI: 10.1016/j.molcel.2006.06.013

Genes

ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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