Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

12 Jul 2016

Abstract excerpt

Claspin transmits replication stress signal from ATR to Chk1 effector kinase as a mediator. It also plays a role in efficient replication fork progression during normal growth. Here we have generated conditional knockout of Claspin and show that Claspin knockout mice are dead by E12.5 and Claspin knockout mouse embryonic fibroblast (MEF) cells show defect in S phase. Using the mutant cell lines, we report the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27401717
DOI: 10.1038/ncomms12135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cellsPMID 27401717Read ↗

Roles of Claspin in regulation of DNA replication, replication stress responses and oncogenesis in human cellsSemantic proximity Read ↗

Mrc1/Claspin: a new role for regulation of origin firing.Semantic proximity Read ↗

Drf1-dependent kinase interacts with Claspin through a conserved protein motif.Semantic proximity Read ↗

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein.Semantic proximity Read ↗

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.Semantic proximity Read ↗

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.Semantic proximity Read ↗

DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response.Semantic proximity Read ↗

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.Semantic proximity Read ↗

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress.Semantic proximity Read ↗

Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.Semantic proximity Read ↗

CDC28 phosphorylates Cac1p and regulates the association of chromatin assembly factor I with chromatin.Semantic proximity Read ↗

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.