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Article

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator.

Genetic epidemiology - 1 May 2016

Bowden Jack, Davey Smith George, Haycock Philip C, Burgess Stephen

Abstract excerpt

Developments in genome-wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward. However, obtaining reliable results from a Mendelian randomization investigation remains problematic, as the conventional inverse-variance weighted method only gives consistent estimates if all of the genetic variants in...

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Identifiers

PMID: 27061298
DOI: 10.1002/gepi.21965
PMCID: PMC4849733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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