Article
A novel two-sample Mendelian randomization framework integrating common and rare variants: application to assess the effect of HDL-C on preeclampsia risk.
Briefings in bioinformatics - 7 Jan 2026
Zhang Yu, Li Ming, Haas David M, Bairey Merz C Noel, Workalemahu Tsegaselassie, Ryckman Kelli, Catov Janet M, Levine Lisa D, Freedman Alexa, Saade George R, Hu Jiaqi, Zhao Hongyu, Li Xihao, Liu Nianjun, Yan Qi
Abstract excerpt
Mendelian randomization (MR) has become an important technique for establishing causal relationships between risk factors and health outcomes. By using genetic variants as instrumental variables, it can mitigate bias due to confounding and reverse causation in observational studies. Current MR analyses have predominantly used common genetic variants as instruments, which represent only part of the genetic...
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