Article
Mendelian randomization of blood lipids for coronary heart disease.
European heart journal - 1 Mar 2015
Holmes Michael V, Asselbergs Folkert W, Palmer Tom M, Drenos Fotios, Lanktree Matthew B, Nelson Christopher P, Dale Caroline E, Padmanabhan Sandosh, Finan Chris, Swerdlow Daniel I, Tragante Vinicius, van Iperen Erik P A, Sivapalaratnam Suthesh, Shah Sonia, Elbers Clara C, Shah Tina, Engmann Jorgen, Giambartolomei Claudia, White Jon, Zabaneh Delilah, Sofat Reecha, McLachlan Stela, Doevendans Pieter A, Balmforth Anthony J, Hall Alistair S, North Kari E, Almoguera Berta, Hoogeveen Ron C, Cushman Mary, Fornage Myriam, Patel Sanjay R, Redline Susan, Siscovick David S, Tsai Michael Y, Karczewski Konrad J, Hofker Marten H, Verschuren W Monique, Bots Michiel L, van der Schouw Yvonne T, Melander Olle, Dominiczak Anna F, Morris Richard, Ben-Shlomo Yoav, Price Jackie, Kumari Meena, Baumert Jens, Peters Annette, Thorand Barbara, Koenig Wolfgang, Gaunt Tom R, Humphries Steve E, Clarke Robert, Watkins Hugh, Farrall Martin, Wilson James G, Rich Stephen S, de Bakker Paul I W, Lange Leslie A, Davey Smith George, Reiner Alex P, Talmud Philippa J, Kivimäki Mika, Lawlor Debbie A, Dudbridge Frank, Samani Nilesh J, Keating Brendan J, Hingorani Aroon D, Casas Juan P
Abstract excerpt
AIMS: To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. METHODS AND RESULTS: We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For...
Read the complete abstract on PubMed