Article
The origin and properties of pro-oncogenic fields in the intestinal epithelium
2020-01-01
Abstract excerpt
The intestinal epithelium is maintained by intestinal stem cells that replace each other stochastically over time. Stem cells that are excluded from the stem cell pool will differentiate into the absorptive or secretory cell lineages. However, intestinal cell-fate specification is not always restrictive and early secretory progenitors can revert back to the stem cell pool. Human colon cancer develops by acquisitio...
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Identifiers and source
- Literature Corpus work
- c0323ffd-7dac-58b6-9d1e-49b95c8c8d39
- DOI
- 10.17863/cam.49274