Article
Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation.
Nature genetics - 1 Jul 2024
Verhagen Mathijs P, Joosten Rosalie, Schmitt Mark, Välimäki Niko, Sacchetti Andrea, Rajamäki Kristiina, Choi Jiahn, Procopio Paola, Silva Sara, van der Steen Berdine, van den Bosch Thierry P P, Seinstra Danielle, de Vries Annemarie C, Doukas Michail, Augenlicht Leonard H, Aaltonen Lauri A, Fodde Riccardo
Abstract excerpt
According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, has been shown to suppress intestinal stemness. Here, we used Paneth cells as a model to assess the capacity of differentiated lineages to trigger tumorigenesis in the context of inflammation in mice. Upon inflammation, Paneth cell-specific Apc mutations led to intestinal tumors...
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