Article

Noncoding regulatory mutations contribute to the aberrant gene expression in neuroblastoma.

2026-08-15

Abstract excerpt

Comprehensive analyses of whole-genome and exome sequencing data from high-risk neuroblastoma tumors have revealed relatively few recurrent, clinically actionable protein-coding driver mutations at initial diagnosis. This observation suggests that noncoding genetic variation, which can alter regulatory sequences like promoters, enhancers and insulators and influence gene expression, may play a critical role in neu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a2b9182-9770-5ce1-b94e-0f0533a6027f
DOI: 10.64898/2026.08.10.743941

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Noncoding regulatory mutations contribute to the aberrant gene expression in neuroblastoma.DOI 10.64898/2026.08.10.743941Read

Transcription Factors Involved in Tumorigenesis Are Over-Represented in Mutated Active DNA-Binding Sites in Neuroblastoma.Semantic proximity Read

Somatic Mutations Enriched in Cis-Regulatory Elements Affect Genes Involved in Embryonic Development and Immune System Response in Neuroblastoma.Semantic proximity Read

Regulatory non-coding somatic mutations as drivers of neuroblastomaSemantic proximity Read

Allele-specific expression links diverse cis-regulatory mutations to recurrent gene dysregulation in high-risk neuroblastomaSemantic proximity Read

Genome-wide analysis of noncoding regulatory mutations in cancer.Semantic proximity Read

Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma.Semantic proximity Read

The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation.Semantic proximity Read

Dissecting the sources of gene expression variation in a pan-cancer analysis identifies novel regulatory mutations.Semantic proximity Read

Alterations in transcriptional networks in cancer: the role of noncoding somatic driver mutations.Semantic proximity Read

The genetics of splicing in neuroblastoma.Semantic proximity Read

RNA-Seq Reveals Allele-Specific Expression of Somatic Mutations in NeuroblastomaSemantic proximity Read

Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma.Semantic proximity Read