Article
The genetics of splicing in neuroblastoma.
Cancer discovery - 1 Apr 2015
Chen Justin, Hackett Christopher S, Zhang Shile, Song Young K, Bell Robert J A, Molinaro Annette M, Quigley David A, Balmain Allan, Song Jun S, Costello Joseph F, Gustafson W Clay, Van Dyke Terry, Kwok Pui-Yan, Khan Javed, Weiss William A
Abstract excerpt
UNLABELLED: Regulation of mRNA splicing, a critical and tightly regulated cellular function, underlies the majority of proteomic diversity and is frequently disrupted in disease. Using an integrative genomics approach, we combined both genomic data and exon-level transcriptome data in two somatic tissues (cerebella and peripheral ganglia) from a transgenic mouse model of neuroblastoma, a tumor that arises from...
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