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Article

Somatic Mutations Enriched in Cis-Regulatory Elements Affect Genes Involved in Embryonic Development and Immune System Response in Neuroblastoma.

Cancer research - 1 Apr 2022

Lasorsa Vito Alessandro, Montella Annalaura, Cantalupo Sueva, Tirelli Matilde, de Torres Carmen, Aveic Sanja, Tonini Gian Paolo, Iolascon Achille, Capasso Mario

Abstract excerpt

Noncoding cis-regulatory variants have gained interest as cancer drivers, yet progress in understanding their significance is hindered by the numerous challenges and limitations of variant prioritization. To overcome these limitations, we focused on active cis-regulatory elements (aCRE) to design a customized panel for the deep sequencing of 56 neuroblastoma tumor and normal DNA sample pairs. To search for driver...

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PMID: 35101866
DOI: 10.1158/0008-5472.CAN-20-3788

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