The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation.

doi:10.1016/j.ccell.2014.09.014

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The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation.

Cancer cell - 10 Nov 2014

Pandey Gaurav Kumar, Mitra Sanhita, Subhash Santhilal, Hertwig Falk, Kanduri Meena, Mishra Kankadeb, Fransson Susanne, Ganeshram Abiarchana, Mondal Tanmoy, Bandaru Sashidhar, Ostensson Malin, Akyürek Levent M, Abrahamsson Jonas, Pfeifer Susan, Larsson Erik, Shi Leming, Peng Zhiyu, Fischer Matthias, Martinsson Tommy, Hedborg Fredrik, Kogner Per, Kanduri Chandrasekhar

Abstract excerpt

Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of...

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PMID: 25517750
DOI: 10.1016/j.ccell.2014.09.014

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