Article
Transcription Factors Involved in Tumorigenesis Are Over-Represented in Mutated Active DNA-Binding Sites in Neuroblastoma.
Cancer research - 1 Feb 2020
Capasso Mario, Lasorsa Vito Alessandro, Cimmino Flora, Avitabile Marianna, Cantalupo Sueva, Montella Annalaura, De Angelis Biagio, Morini Martina, de Torres Carmen, Castellano Aurora, Locatelli Franco, Iolascon Achille
Abstract excerpt
The contribution of coding mutations to oncogenesis has been largely clarified, whereas little is known about somatic mutations in noncoding DNA and their role in driving tumors remains controversial. Here, we used an alternative approach to interpret the functional significance of noncoding somatic mutations in promoting tumorigenesis. Noncoding somatic mutations of 151 neuroblastomas were integrated with ENCODE...
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