Article
Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma.
Nature genetics - 1 Jun 2017
Feigin Michael E, Garvin Tyler, Bailey Peter, Waddell Nicola, Chang David K, Kelley David R, Shuai Shimin, Gallinger Steven, McPherson John D, Grimmond Sean M, Khurana Ekta, Stein Lincoln D, Biankin Andrew V, Schatz Michael C, Tuveson David A
Abstract excerpt
The contributions of coding mutations to tumorigenesis are relatively well known; however, little is known about somatic alterations in noncoding DNA. Here we describe GECCO (Genomic Enrichment Computational Clustering Operation) to analyze somatic noncoding alterations in 308 pancreatic ductal adenocarcinomas (PDAs) and identify commonly mutated regulatory regions. We find recurrent noncoding mutations to be...
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